Cardioselective antiischemic ATP-sensitive potassium channel (KATP) openers. 5. Identification of 4-(N-aryl)-substituted benzopyran derivatives with high selectivity

…, AJ Baird, LG McLaughlin, DE Normandin…

Index: Rovnyak, George C.; Ahmed, Syed Z.; Ding, Charles Z.; Dzwonczyk, Steven; Ferrara, Francis N.; Humphreys, W. Griffith; Grover, Gary J.; Santafianos, Dinos; Atwal, Karnail S.; Baird, Anne J.; McLaughlin, Lee G.; Normandin, Diane E.; Sleph, Paul G.; Traeger, Sarah C. Journal of Medicinal Chemistry, 1997 , vol. 40, # 1 p. 24 - 34

Full Text: HTML

Citation Number: 85

Abstract

This paper describes our studies aimed at the discovery of structurally distinct analogs of the cardioprotective KATP opener BMS-180448 (2) with improved selectivity for the ischemic myocardium. The starting compound 6, derived from the indole analog 4, showed good cardioprotective potency and excellent selectivity compared to 2 and the first-generation KATP opener cromakalim (1). The structure-activity studies indicate that increasing the ...