The Journal of Organic Chemistry

Nickel-catalyzed reaction of iododifluoroacetates with alkenes and zinc: a novel and practical route to. alpha.,. alpha.-difluoro-functionalized esters and. alpha.,. alpha. …

ZY Yang, DJ Burton

Index: Yang, Zhen-Yu; Burton, Donald J. Journal of Organic Chemistry, 1992 , vol. 57, # 19 p. 5144 - 5149

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Citation Number: 63

Abstract

Iododifluoroacetates la-c react with alkenes and zinc in the presence of nickel dichloride hexahydrate in THF at room temperature or 60 OC to give the corresponding a, a-difluoro esters in good yields. The reaction is also applicable to alkenes containing a variety of functional groups such as trimethylsilyl, hydroxy, ketone, and ester moieties. The reaction of 1 works well with dienes; the products formed depend on the length of chain of the dienes. ...