Mn-mediated coupling of alkyl iodides and chiral N-acylhydrazones: Optimization, scope, and evidence for a radical mechanism

GK Friestad, JC Marié, YS Suh…

Index: Gilbert, Bruce C.; Lindsay, Chris I.; McGrail, P. Terry; Parsons, Andrew F.; Whittaker, David T.E. Synthetic Communications, 1999 , vol. 29, # 15 p. 2711 - 2718

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Citation Number: 43

Abstract

... Interestingly, Parsons noted that reaction of • Mn(CO) 5 with 1° halides was much more facile than with 2° or 3° halides. ... Addition of methyl iodide gives S configuration due to the lower priority of the methyl ligand. c 20 equiv of R 2 X was used. ... f Ratio by 1 H NMR. ...