A New Class of Non??Racemic Chiral Macrocycles: A Conformational and Synthetic Study

SE Gibson, N Mainolfi, SB Kalindjian…

Index: Gibson, Susan E.; Mainolfi, Nello; Kalindjian, S. Barret; Wright, Paul T.; White, Andrew J. P. Chemistry - A European Journal, 2005 , vol. 11, # 1 p. 69 - 80

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Citation Number: 21

Abstract

Abstract Amino alcohols have been used to introduce non-racemic chirality into macrocycles using a modular approach that relies on a Heck macrocyclisation reaction. A wide variety of macrocycles have been synthesised, and their structures studied using X-ray crystallography and molecular modelling. A fragmentation reaction encountered during the use of (S)-1, 1-dimethylvalinol revealed that carboxylic acids generate acylals under ...