Annonaceous acetogenin mimics bearing a terminal lactam and their cytotoxicity against cancer cells

…, GR Huang, HM Zhang, JR Wu, ZJ Yao

Index: Liu, Hai-Xia; Huang, Guo-Rui; Zhang, Huan-Ming; Wu, Jia-Rui; Yao, Zhu-Jun Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 12 p. 3426 - 3430

Full Text: HTML

Citation Number: 23

Abstract

Annonaceous acetogenins are a large class of naturally occurring polyketides exhibiting potent anticancer activities. Based on our previous discovery of AA005, a multi-ether mimic of natural acetogenins having potent antitumor activities and significant selectivity between normal cells and cancer cells, a new series of mimics containing a terminal lactam were designed, synthesized and evaluated. Bioactivity study against cancer cells shows that the ...