The Journal of organic chemistry

Microwave-assisted one-pot synthesis of 1-indanones from arenes and α, β-unsaturated acyl chlorides

W Yin, Y Ma, J Xu, Y Zhao

Index: Yin, Wei; Ma, Yuan; Xu, Jiaxi; Zhao, Yufen Journal of Organic Chemistry, 2006 , vol. 71, # 11 p. 4312 - 4315

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Citation Number: 74

Abstract

First, we used identical conditions as reported by Koelsch et al. with crotonic acid and benzene as starting materials. 12 However, we failed to achieve the literature's yield (81.5%; a very low yield was obtained) in repeating the reaction several times. Instead, crotonic acid was recovered in all cases. To improve reactivity, we used more active crotonoyl chloride instead of crotonic acid and obtained a mixture of 3-methyl-1- indanone, 1-phenyl-but-2-en-1-one, and 1,3- ...