European journal of medicinal chemistry

Synthesis and preliminary evaluation of perfluoroalkylacyl carnitines as surfactants for biomedical use

JB Nivet, M Le Blanc, JG Riess

Index: Nivet, JB; Blanc, M Le; Riess, JG European Journal of Medicinal Chemistry, 1991 , vol. 26, # 9 p. 953 - 960

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Citation Number: 15

Abstract

Abstract A series of acyl carnitines, 4 of which bearing a terminal perfluoroalkyl fragment, was obtained from carnitine in one step in a high grade of purity in yields ranging from 44– 81%. The F-alkyl derivatives display high solubilities in water, strong surface activity and a significant emulsifying power towards fluorocarbons in water. In spite of their strong surface activity, all the biocompatibility tests performed (in vitro toxicity on Namalva cells cultures, ...