The synthesis of. ALPHA.-aminonitriles starting from the corresponding amino acids. I. Use of o-nitrophenylsulfenyl as an N-protecting group.

K Kawashiro, H Yoshida, S Morimoto

Index: Kawashiro,K. et al. Bulletin of the Chemical Society of Japan, 1977 , vol. 50, p. 2956 - 2960

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Citation Number: 7

Abstract

No-Nitrophenylsulfenylamino acid amides of glycine, alanine (DL and L), leucine (DL and L), methionine (DL), phenylalanine (DL and L), and proline (L) were dehydrated in POCl 3- pyridine. The N-protected α-amino-nitriles obtained were treated with anhydrous HCl affording the corresponding α-aminonitrile hydrochlorides. The optical purity of the L-α- aminonitriles was well retained.