Analogs of platelet activating factor. 6. Mono-and bis-aryl phosphate antagonists of platelet activating factor

…, ML Carroll, KE Green, SS Kerwar…

Index: Wissner, A.; Carroll, M. L.; Green, K. E.; Kerwar, S. S.; Pickett, W. C.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 9 p. 1650 - 1662

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Citation Number: 40

Abstract

A series of aryl phosphoglyceride (3, 1941) and bis-aryl phosphate (67-135) antagonists of platelet activating factor (PAF) were prepared. A group of four bifunctional phosphorus reagents (5a-c and 7) were developed that allowed the preparation of the aryl phosphates in which the poeition of aromatic substitution can be varied. These compounds were examined for their ability to inhibit PAF-induced platelet aggregation of rabbit platelets. Selected ...