In our pursuit of superior agonists of the G-protein coupled receptor 119 (GPR119) we were interested in constrained analogs of compound 1 (Fig. 1). 1 and 2 To achieve this conformational goal while incorporating superior physicochemical properties (lower C log P), we envisioned the use of a dihydro-6H-pyrano[2,3-6]pyrazine ring system as exemplified by compound 2. ... Pyridyl-ether versus dihydro-6H-pyrano[2,3-6]pyrazine. Pyridyl-ether versus dihydro-6H-pyrano[2,3-6] ...
