Tetrahedron Letters

Microwave-assisted synthesis of 1-aminoalkyl phosphonates under solvent-free conditions

B Kaboudin, R Nazari

Index: Kaboudin, Babak; Nazari, Rahman Tetrahedron Letters, 2001 , vol. 42, # 46 p. 8211 - 8213

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Citation Number: 201

Abstract

A simple, efficient and general method has been developed for the synthesis of 1-aminoalkyl phosphonates through a one-pot reaction of aldehydes with amines in the presence of acidic alumina under solvent-free conditions using microwave irradiation. It was also found that acidic alumina supported ammonium formate under solvent-free conditions is capable of the synthesis of 1-aminophosphonates from aldehydes and diethyl phosphite under ...