Novel compounds possessing potent cAMP and cGMP phosphodiesterase inhibitory activity. Synthesis and cardiovascular effects of a series of imidazo [1, 2-a] …

…, PW Erhardt, EH Cantor, SS Greenberg…

Index: Davey; Erhardt; Cantor; Greenberg; Ingebretsen; Wiggins Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2671 - 2677

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Citation Number: 51

Abstract

A series of novel imidazoquinoxalinones and their aza analogues were prepared by the cyclization of o-mino (1H-imidazol-1-y1) aryls and heteroaryls with carbonyldiimidazole. The compounds were screened for inhibition of Type I and Type IV phosphodiesterases (PDE's) and evaluated for their vasorelaxant and positive inotropic activities in vitro. In general, compounds having potent PDE inhibitory activity also possessed good inotropic and ...