Minor groove DNA binders as antimicrobial agents. 1. Pyrrole tetraamides are potent antibacterials against vancomycin resistant Enteroccoci and methicillin resistant …

…, Y Dai, JP Nadherny, W Zhang, U Schmitz…

Index: Dyatkina, Natalia B.; Roberts, Christopher D.; Keicher, Jesse D.; Dai, Yuqin; Nadherny, Joshua P.; Zhang, Wentao; Schmitz, Uli; Kongpachith, Ana; Fung, Kevin; Novikov, Alexander A.; Lou, Lillian; Velligan, Mark; Khorlin, Alexander A.; Chen, Ming S. Journal of Medicinal Chemistry, 2002 , vol. 45, # 4 p. 805 - 817

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Citation Number: 86

Abstract

A new series of short pyrrole tetraamides are described whose submicromolar DNA binding affinity is an essential component for their strong antibacterial activity. This class of compounds is related to the linked bis-netropsins and bis-distamycins, but here, only one amino-pyrrole-carboxamide unit and an amidine tail is connected to either side of a central dicarboxylic acid linker. The highest degree of DNA binding, measured by compound- ...