Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties

…, L Testai, T Tuccinardi, R Ghidoni, M Macchia

Index: Bertini, Simone; Calderone, Vincenzo; Carboni, Isabella; Maffei, Roberta; Martelli, Alma; Martinelli, Adriano; Minutolo, Filippo; Rajabi, Mehdi; Testai, Lara; Tuccinardi, Tiziano; Ghidoni, Riccardo; MacChia, Marco Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 18 p. 6715 - 6724

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Citation Number: 22

Abstract

New resveratrol (RES) analogs were developed by replacing the aromatic 'core'of our initial naphthalene-based RES analogs with pseudo-heterocyclic (salicylaldoxime) or heterocyclic (benzofuran, quinoline, and benzothiazole) scaffolds. The resulting analogs were tested for their antiproliferative and vasorelaxing effect, two typical properties shown by RES. Some of the new compounds confirmed strong antiproliferative activities, comparable to that ...