Nucleosides, Nucleotides, and Nucleic Acids

Synthesis and properties of oligonucleotides containing a cholesterol thymidine monomer

A Durand, T Brown

Index: Durand, Adeline; Brown, Tom Nucleosides, Nucleotides and Nucleic Acids, 2007 , vol. 26, # 6-7 p. 785 - 794

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Citation Number: 8

Abstract

Highly selective base-pair recognition makes DNA a suitable building block for orderly self- assembled structures. For some applications in nanotechnology DNA complexes need to be fixed onto surfaces. To fulfil this requirement on lipid membranes we have synthesised a thymidine monomer modified with a cholesterol moiety. Solution studies show that the melting temperature (T m) of the duplex, with adjacent cholesterols on each strand, is ...