Hypervalent Iodine Mediated para-Selective Fluorination of Anilides

T Tian, WH Zhong, S Meng, XB Meng…

Index: Tian, Tian; Zhong, Wen-He; Meng, Shuai; Meng, Xiang-Bao; Li, Zhong-Jun Journal of Organic Chemistry, 2013 , vol. 78, # 2 p. 728 - 732

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Citation Number: 24

Abstract

A metal-free method for the direct regioselective fluorination of anilides has been developed. In the presence of bis (tert-butylcarbonyloxy) iodobenzene (PhI (OPiv) 2) and hydrogen fluoride-pyridine, the para-fluorination products of anilides were obtained in moderate to good yields. Because of its operational safety and the use of readily available reagents, this new procedure provides facile access to a variety of para-fluorinated anilides.