Synthesis and antiviral activity of several 2, 5'-anhydro analogs of 3'-azido-3'-deoxythymidine (AZT), 3'-azido-2', 3'-dideoxyuridine (AZU), 3'-azido-2', 3'-dideoxy-5- …

TS Lin, ZY Shen, EM August, V Brankovan…

Index: Lin, Tai-Shun; Shen, Zhi-Yi; August, E. Michael; Brankovan, Vera; Yang, Hyekyung; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1891 - 1895

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Citation Number: 35

Abstract

3 “The ICm values represent the drug concentration (in pM) required to inhibit 50% of viral replication. bThe TCIDw values represent the drug concentration (in pM) required to inhibit 50% of host cell replication. Nd: not determined. that inhibits viral replication by 50%. In general, the parent compounds AZT (l), AZU (2), 3'-azido-2', 3'-dideoxy-5-bromouridine (3), and 3'-azido-2', 3'-dideoxy-5-iodouridine (4) were approximately 1.8-6 times more active ...