Heterocyclic quinones. XVII. A new in vivo active antineoplastic drug: 6, 7-bis (1-aziridinyl)-4-[[3-(N, N-dimethylamino) propyl] amino]-5, 8-quinazolinedione

…, J Renault, P Gebel-Servolles, M Baron…

Index: Giorgi-Renault; Renault; Gebel-Servolles; Baron; Paoletti; Cros; Bissery; Lavelle; Atassi Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 38 - 46

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Citation Number: 16

Abstract

A series of heterocyclic quinones, 6-substituted and 6, 7-disubstituted 4-(alkylamino)-5, 8- quinazolinediones, have been synthesized in order to evaluate their in vitro cytotoxicity on L1210 leukemia cells. Among 14 derivatives that have been prepared and studied for the structure-activity relationship, the most potent cytotoxic compound on L1210 leukemia cells was the 6, 7-bis (l-aziridinyl)-4-[[3-(NJV-dimethylamino) propyl] amino]-5, 8- ...