Synthesis and anticholinesterase activity of thioesters of chlorofluoronitroacetic acid

YY Ivanov, VI Uvarov, VK Brel', IV Martynov

Index: Ivanov, Yu. Ya.; Uvarov, V. I.; Brel', V. K.; Martynov, I. V. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 5 p. 356 - 358 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 5 p. 538 - 540

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Abstract

Butyl Chlorofluoronitrothioacetate (Ib). Chlorofluoronitroacetic acid (4.5 g, 0.029 mole) was added with stirring to 6 g of PC1 s at 25~ and the reaction mixture was distilled. The fraction with bp 97-102~ was treated with a small excess of butyl mercaptan. Vacuum distillation gave 3.65 g (55%) of Ib, bp 80~(2 mm Hg), n~~ 1.4540; d~~ 1.384. Found,%: C 30.82; H 2.93; F 8.21; S 14.01, C6HgCIFNO3S. Calculated,%: C 31.40; H 3.92; F 8.30; S 13.91. IR ...