Several series of pseudomonic acid analogues have been prepared that incorporate modified functionalities in place of the Cl-C3 a, p-unsaturated ester group. The inhibition of isoleucyl-tRNA synthetase and the in vitro activity of these compounds against various Gram- positive and Gram-negative strains are described. Several derivatives showed enzyme inhibition equivalent to or better than that of methyl pseudomonate (3), while lacking the ...
