[6??chloro??3??pyridylmethyl??3H] neonicotinoids as high??affinity radioligands for the nicotinic acetylcholine receptor: Preparation using NaB3H4 and LiB3H4

…, H Morimoto, PG Williams, JE Casida

Index: Latli, Bachir; Than, Chit; Morimoto, Hiromi; Williams, Philip G.; Casida, John E. Journal of Labelled Compounds and Radiopharmaceuticals, 1996 , vol. 38, # 11 p. 971 - 978

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Citation Number: 24

Abstract

Abstract NaB 3 H 4 and LiB 3 H 4 at 78% and 97% isotopic enrichments, respectively, were used in the synthesis of 3 H-labeled 1-(6-chloro-3-pyridyl)-methyl-2- nitromethyleneimidazolidine (CH-IMI) and N′-[(6-chloro-3-pyridyl) methyl]-N ″-cyano-N′- methylacetamidine (acetamiprid)(two very potent insecticides) and of 1-(6-chloro-3-pyridyl) methyl-2-iminoimidazolidine (desnitro-IMI)(a metabolite of the commercial insecticide ...