Novel Acyclic Nucleotides and Nucleoside 5'-Triphosphates Imitating 2', 3'-Dideoxy-2', 3'-didehydro nucleotides: Synthesis and Biological Properties

EA Shirokova, NB Tarussova, AV Shipitsin…

Index: Shirokova; Tarussova; Shipitsin; Semizarov; Krayevsky Journal of Medicinal Chemistry, 1994 , vol. 37, # 22 p. 3739 - 3748

Full Text: HTML

Citation Number: 13

Abstract

A series of pyrophosphoryl (Z)-(phosphonomethoxy) but-2-enyl derivatives of pyrimidines and purines 9a-d and the corresponding phosphonates 10a-d were synthesized. The prepared compounds contain the phosphonate group as an a-phosphate mimic as well as an acyclic residue emulating the sugar moiety in 2', 3'-dideoxy-2', 3'-didehydronucleoside 5'- triphosphates known as highly potent chain terminators of DNA polymerases. ...