Synthesis and biological activity of 5-fluoroalkylthio-6-azauridines

VI Kobylinskaya, TA Dashevskaya, AS Shalami…

Index: Kobylinskaya, V. I.; Dashevskaya, T. A.; Shalami, A. S.; Suleimanov, S. P.; Kharchuk, A. N.; Protopopova, G. V. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 3 p. 179 - 182 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 3 p. 290 - 292

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Abstract

The three-step synthesis of 5-f! uoroalkyithio-6-azauridines (XI-XIIi) consists of the silylation of 5-difluoromethylthio-(1), 5-trif! uoromethylthio-(ll), and 5-perfluoropropylthio-(III) of 6- azauracyls by hexamethyldisilazane (HMDS) and trimethy! chl0rosilane (TMCS) and subsequent condensation of the si! yl derivatives (IV-V!) with iO-acetyl-2, 3, 5-tri-O-benzoyl-D- ribofuranose (VII) in the presence of a quantity of trimethyliodosilane that is triple that of ...