Steroids

[125 I] Iododesethyl tamoxifen aziridine: Synthesis and covalent labeling of the estrogen receptor with an iodine-labeled affinity label

…, BS Katzenellenbogen, JA Katzenellenbogen

Index: Salituro; Carlson; Elliston; Katzenellenbogen Steroids, 1986 , vol. 48, # 5-6 p. 287 - 313

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Citation Number: 5

Abstract

Abstract Iododesethyl tamoxifen aziridine (I-Tam-Az), an analog of the estrogen receptor- affinity label tamoxifen aziridine (Tam-Az) in which the ethyl group has been replaced by an iodine, has been prepared by two routes:(a) metallation of a bromotriarylethylene system, followed by reaction with iodine, and aziridinylation, and (b) direct iodination of a trimethylstannyl triarylethylene system that is the immediate precursor of I-Tam-Az. The ...