e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Block of human Na V 1.5 sodium channels by novel α-hydroxyphenylamide analogues of phenytoin
PW Lenkowski, SH Ko, JD Anderson, ML Brown…
Index: Lenkowski, Paul W.; Ko, Seong-Hoon; Anderson, James D.; Brown, Milton L.; Patel, Manoj K. European Journal of Pharmaceutical Sciences, 2004 , vol. 21, # 5 p. 635 - 644
Voltage-gated sodium (Na) channels are a critical component of electrically excitable cells. Phenytoin (diphenylhydantoin, DPH) is an established sodium channel blocker and is a useful anticonvulsant and class 1b antiarrhythmic, and has been effectively used in the treatment of neuropathic pain. In this study, we have synthesized novel α- hydroxyphenylamide analogues of diphenylhydantoin and examined their ability to inhibit ...