Application of iridium catalyzed allylic substitution reactions in the synthesis of branched tryptamines and homologues via tandem hydroformylation–Fischer indole …

…, A Farwick, J Liebich, P Eilbracht

Index: Bondzic, Bojan P.; Farwick, Andreas; Liebich, Jens; Eilbracht, Peter Organic and Biomolecular Chemistry, 2008 , vol. 6, # 20 p. 3723 - 3731

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Citation Number: 30

Abstract

Combination of enantioselective allylation reactions with a tandem hydroformylation–Fischer indole synthesis sequence as a highly diversity-oriented strategy for the synthesis of tryptamines and homologues was explored. This modular approach allows the substituents at C3 of the indole core, the type of the amine moiety, and the distance of the amine moiety to the indole core in the final synthetic step to be defined. The starting materials required ...