Tetrahedron

Synthesis of ethyl 3-alkyl-4-oxochroman-3-carboxylates and their conversion to some derivatives

B Loubinoux, JL Colin, B Antonot-Colin, L Lalloz

Index: Loubinoux, Bernard; Colin, Jean-Luc; Antonot-Colin, Brigitte; Lalloz, Lucien Tetrahedron, 1987 , vol. 43, # 1 p. 93 - 100

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Citation Number: 15

Abstract

A series of ethyl 3-alkyl-4-oxochroman-3-carboxylates 5 was synthesized and some representative reactions were attempted on these compounds. The first step of the synthesis was the condensation of diethyl alkylsodiomalonates on aryloxymethyl chlorides. Hydrolysis of one ester group and treatment with thionyl chloride afforded the mono acyl halides which were cyclized by means of aluminium chloride.