Synthesis of an antitumour alkaloid sinococuline from sinomenine

…, H Ikuta, K Nishimura, K Takeya, H Itokawa

Index: Hitotsuyanagi, Yukio; Ikuta, Hiroshi; Nishimura, Kunihiko; Takeya, Koichi; Itokawa, Hideji Journal of the Chemical Society, Chemical Communications, 1994 , # 23 p. 2707 - 2708

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Abstract

An antiturnour morphinane alkaloid sinococuline 1 is synthesised from sinomenine 2 in an efficient manner. ... Sinococuline 1 is a morphinane alkaloid isolated from the roots of the plant Coccufus trifobusl and shows promising antitumour activity against animal tumour models. However, the quantity of 1 in the plant is variable and its high polar and noncrystallizable property makes isolatiordpurification diffi- cult. These difficulties have hampered further preclinical studies of 1 as an ...