Tetrahedron Letters

A facile procedure for the one-pot synthesis of unsymmetrical 2, 5-disubstituted 1, 3, 4-oxadiazoles

…, P Salehi, M Baghbanzadeh, M Bahramnejad

Index: Dabiri, Minoo; Salehi, Peyman; Baghbanzadeh, Mostafa; Bahramnejad, Mahboobeh Tetrahedron Letters, 2006 , vol. 47, # 39 p. 6983 - 6986

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Citation Number: 109

Abstract

Unsymmetrically 2, 5-disubstituted 1, 3, 4-oxadiazoles were efficiently synthesized from the cyclization–oxidation reaction of acyl hydrazones. Also, the synthesis of the title compounds was achieved by the condensation of acyl hydrazides and aromatic aldehydes in the presence of ceric ammonium nitrate in dichloromethane.