Chinese Chemical Letters

The convenient synthesis of 4-arylmethylidene-4, 5-dihydro-3-phenylisoxazol-5-ones

K Ablajan, H Xiamuxi

Index: Ablajan, Keyume; Xiamuxi, Hainimu Chinese Chemical Letters, 2011 , vol. 22, # 2 p. 151 - 154

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Citation Number: 22

Abstract

4-Arylmethylidene-4, 5-dihydro-3-phenylisoxazol-5-ones were synthesized by the convenient three-component reaction of ethyl benzoylacetate, hydroxylamine and aromatic aldehydes in the presence of pyridine. The target compounds were also obtained by the reaction between 3-phenylisoxazol-5-one and aromatic aldehydes at 105° C under solvent free condition. Yields of products depended considerably on the aldehyde used.