852 J. Org. Chem., Vol. 57, No. 3, 1992 efficacy and side-effect profile of these agents vis- 84s older classes of antihypertensive agents have led to their wide acceptance in medical practice. There are three major groups of calcium channel blockers, identified by structural types and represented by diltiazem (l), verapamil (21, and the dihydropyridines (nifedipine (3), etc.). Diltiazem has emerged as one of the most important agents of this group in ...
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