New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein

X Liu, X Huang, W Lin, D Wang, Y Diao, H Li…

Index: Liu, Xiujie; Huang, Xiaoli; Lin, Wanhua; Wang, Dongye; Diao, Yanyan; Li, Honglin; Hui, Xiaoyan; Wang, Yu; Xu, Aimin; Wu, Donghai; Ke, Ding Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 2949 - 2952

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Citation Number: 23

Abstract

Abstract a-FABP is indespensible in inflammation and may serve as a new potential drug target for inflammation related diseases. We have successfully designed and synthesized a series of aromatic substituted pyrazoles as new human a-FABP inhibitors. The compounds strongly bound to the hydrophobic binding pocket of a-FABP, while showed significantly lower binding affinities to the closely related homologue protein h-FABP. The most potent ...