Antitumor agents. 86. Synthesis and cytotoxicity of. alpha.-methylene-. gamma.-lactone-bearing purines

…, GK Rice, IH Hall, V Amarnath

Index: Lee, Kuo-Hsiung; Rice, Gregory K.; Hall, Iris H.; Amarnath, Venkataraman Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 586 - 588

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Citation Number: 15

Abstract

Natural Products Laboratory, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, The University of North Carolina, Chapel Hill, North Carolina 27514. Received June 23, 1986 a-Methylene-y-lactones covalently linked to adenine (3), hypoxanthine (4), and guanine (5) were synthesized by using the convenient Reformatsky-type reaction between ethyl a-(bromomethy1) acrylate and the proper purine ketones. In vitro ...