Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonists

…, WD Cash, S Psychoyos, G Ghai, P Wenk…

Index: Francis, John E.; Cash, William D.; Psychoyos, Stacy; Ghai, Geetha; Wenk, Paul; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 1014 - 1020

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Citation Number: 128

Abstract

During a search for benzodiazepine receptor modulators, a highly potent adenosine antagonist (CGS 15943) was discovered. The compound was defined as a resonance- stabilized hybrid of the canonical structures 9-chloro-2-(2-furyl)[1, 2, 4] triazolo [1, 5-c] quinazolin-5-amine (2a) and 9-chloro-2-(2-furyl)-5, 6-dihydro [l, 2, 4] triazolo [1, 5-c]- quinazolin-5-imine (2b). Spectroscopic evidence and chemical reactivity in polar media ...