Amino acid amides of 2-[(2-aminobenzyl) sulfinyl] benzimidazole as acid-stable prodrugs of potential inhibitors of H+ K+ ATPase

K Hirai, H Koike, T Ishiba, S Ueda, I Makino…

Index: Hirai, K; Koike, H; Ishiba, T; Ueda, S; Makino, I; et al. European Journal of Medicinal Chemistry, 1991 , vol. 26, # 2 p. 143 - 158

Full Text: HTML

Citation Number: 11

Abstract

Abstract A series of amino acid amides of 2-[(2-aminobenzyl) sulfinyl] benzimidazole were prepared and found to possess gastric antisecretory activity on oral administration.( Glycylaminobenzyl) sulfinyl compound 23a, stable in artificial gastric juice (pH 1.2), was given orally to dogs. It was absorbed efficiently and converted into aniline derivative 7a which showed a very high plasma concentration. Compound 23a was hydrolyzed by the ...