Biological properties of amidinium sulfinic and sulfonic acid derivatives: inhibition of glycolytic enzymes of Trypanosoma brucei and protective effect on cell growth

M Willson, JJ Perie, F Malecaze, F Opperdoes…

Index: Willson, M; Perie, JJ; Malecaze, F; Opperdoes, F; Callens, M European Journal of Medicinal Chemistry, 1992 , vol. 27, # 8 p. 799 - 808

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Citation Number: 7

Abstract

Abstract The activity of the title compounds has been investigated on two biological targets: cultures of trypanosome and glycolytic enzymes inhibition of the parasite, and on retinal epithelium cells. In both cases, these compounds exhibit a significant activity, in some cases more selective than this for the drug suramin, with a lower toxicity. The effect of these compounds, which exist as neutral and zwitterionic forms in the case of sulfinic, only as ...