Synthesis and stereochemistry of (3α)??6β, 7β??dihydroxy??and 6β??hydroxy??8??alkyl??8??azabicyclo [3.2. 1] octane??3??spiro??5′??imidazoline??2′, 4′??diones

…, G González??Trigo, MNM Söllhuber

Index: Villacampa; Martinez; Gonzalez-Trigo; Sollhuber Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 6 p. 1541 - 1544

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Citation Number: 8

Abstract

Abstract The synthesis of 6β-hydroxy-and 6β, 7β-dihydroxy-8-alkyl-8-azabicyclo [3.2. 1] octane-3-spiro-5′-hydantoins was stereoselectively achieved by Bucherer-Bergs reaction of the corresponding ketones. An α configuration on C 3 was proposed for all hydantoins on the basis of spectral data.