1-[(Imidazolidin-2-yl) imino] indazole. highly α2/I1 selective agonist: Synthesis, X-ray structure, and biological activity

…, A Kornicka, A Rybczyńska, AL Hudson…

Index: Saczewski, Franciszek; Kornicka, Anita; Rybczynska, Apolonia; Hudson, Alan L.; Shu, Sean Miao; Gdaniec, Maria; Boblewski, Konrad; Lehmann, Artur Journal of Medicinal Chemistry, 2008 , vol. 51, # 12 p. 3599 - 3608

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Citation Number: 26

Abstract

Novel benzazole derivatives bearing a (imidazolidin-2-yl) imino moiety at position 1 or 2 were synthesized by reacting 1-amino-or 2-aminobenzazoles with N, N′-bis (tert- butoxycarbonyl) imidazolidine-2-thione in the presence of HgCl2. Structures of 1- [(imidazolidin-2-yl) imino] indazole (marsanidine, 13a) and free base of the 4-Cl derivative 12e were confirmed by X-ray single crystal structure analysis. Compound 13a was found ...