Structure-activity relationship of antiestrogens. A study using triarylbutenone, benzofuran, and triarylfuran analogs as models for triarylethylenes and triarylpropenones

…, A Saeed, DK Dikshit, S Durani, RS Kapil

Index: Durani; Jain; Saeed; Dikshit; Kapil Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1700 - 1707

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Citation Number: 36

Abstract

In a study of the structure-activity relationship (SAR) of antiestrogens use has been made of certain 1, 2, 3-triarylbutenones, of 2-arylbenzofurans carrying aryl or aroyl substituents at C3, and of 2, 3, 4-triarylfurans as conformationally constrained models for triarylethylene (TAE) and triarylpropenone (TAP) prototypes. The position-specific contributions of substituents to receptor affinity and to agonist-antagonist profiles were used as aids in characterizing the ...