Synthesis and biological activity of acyl derivatives of 4-amino-2, 3-dimethyl-1-phenylpyrazol-5-one

VG Voronon, ZI Shramova, VA Aleshina…

Index: Voronon, V. G.; Shramova, Z. I.; Aleshina, V. A.; Zaks, A. S.; Pidemskii, E. L.; Goleneva, A. F. Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 6 p. 396 - 399 Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 6 p. 35 - 39

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Abstract

The synthesis of compound (I) was accomplished by the interaction of 4-methyi- aminopyrene or its hydrochloride with 3, 4, 5-trimethoxybenzoic acid or its functional derivatives, such as the acid chloride or anhydride, in the presence of a dehydration or dehydrohalogena~ tion agent. Phosphorus oxychloride, thionyl chloride, phosphorus trichloride, phosphorus pentachloride, and the like can be used as dehydrating agents. As ...