Photodynamic Antitumor Agents:. beta.-Methoxyethyl Groups Give Access to Functionalized Porphycenes and Enhance Cellular Uptake and Activity

…, M Mueller, M Kisters, T Benninghaus…

Index: Richert; Wessels; Muller; Kisters; Benninghaus; Goetz Journal of Medicinal Chemistry, 1994 , vol. 37, # 17 p. 2797 - 2807

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Citation Number: 87

Abstract

Porphycene photosensitizers bearing two or four methoxyethyl side chains were synthesized in nine steps from commercially available starting materials. Ether cleavage led to (hydroxyethyl)-and (bromoethy1) porphycenes that were converted to vinyl and benzo derivatives. Five of the side chain-functionalized porphycenes were biologically studied in comparison with two tetra-n-propylporphycenes. Porphycenes were incorporated in small ...