e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

NO-independent stimulators of soluble guanylate cyclase

…, JP Stasch, C Alonso-Alija, J Benet-Buchholz…

Index: Straub, Alexander; Stasch, Johannes-Peter; Alonso-Alija, Cristina; Benet-Buchholz, Jordi; Ducke, Bernhard; Feurer, Achim; Fuerstner, Chantal Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 781 - 784

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Citation Number: 141

Abstract

SARs around a novel type of guanylate cyclase stimulator which act by a mechanism different from classical NO-donors are described. Several pyrazolopyridinylpyrimidines are shown to relax aortic rings and revealed a long-lasting blood pressure lowering effect in rats after oral application.

(2-Fluorobenzyl)hydrazine Structure

(2-Fluorobenzyl...

~%

1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridine-3-carbonitrile Structure

1-[(2-fluorophe...

Ethyl 5-amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate Structure

Ethyl 5-amino-1...

~%

1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridine-3-carbonitrile Structure

1-[(2-fluorophe...

1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid ethyl ester Structure

1-(2-fluorobenz...

~%

1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridine-3-carbonitrile Structure

1-[(2-fluorophe...

(2-Fluorobenzyl)hydrazine Structure

(2-Fluorobenzyl...

~%

1H-Pyrazolo[3,4-b]pyridine-3-carboximidamide, 1-[(2-fluorophenyl)Methyl]- Structure

1H-Pyrazolo[3,4...

Ethyl 5-amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate Structure

Ethyl 5-amino-1...

~%

1H-Pyrazolo[3,4-b]pyridine-3-carboximidamide, 1-[(2-fluorophenyl)Methyl]- Structure

1H-Pyrazolo[3,4...

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide Structure

1-(2-Fluorobenz...

~%

1H-Pyrazolo[3,4-b]pyridine-3-carboximidamide, 1-[(2-fluorophenyl)Methyl]- Structure

1H-Pyrazolo[3,4...

1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid ethyl ester Structure

1-(2-fluorobenz...

~%

1H-Pyrazolo[3,4-b]pyridine-3-carboximidamide, 1-[(2-fluorophenyl)Methyl]- Structure

1H-Pyrazolo[3,4...

Identification of acidic heterocycle-substituted 1H-pyrazolo...

[Griebenow, Nils; Schirok, Hartmut; Mittendorf, Joachim; Straub, Alexander; Follmann, Markus; Stasch, Johannes-Peter; Knorr, Andreas; Schlemmer, Karl-Heinz; Redlich, Gorden Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1197 - 1200]

Identification of acidic heterocycle-substituted 1H-pyrazolo...

[Griebenow, Nils; Schirok, Hartmut; Mittendorf, Joachim; Straub, Alexander; Follmann, Markus; Stasch, Johannes-Peter; Knorr, Andreas; Schlemmer, Karl-Heinz; Redlich, Gorden Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1197 - 1200]

Identification of acidic heterocycle-substituted 1H-pyrazolo...

[Griebenow, Nils; Schirok, Hartmut; Mittendorf, Joachim; Straub, Alexander; Follmann, Markus; Stasch, Johannes-Peter; Knorr, Andreas; Schlemmer, Karl-Heinz; Redlich, Gorden Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1197 - 1200]

Identification of acidic heterocycle-substituted 1H-pyrazolo...

[Griebenow, Nils; Schirok, Hartmut; Mittendorf, Joachim; Straub, Alexander; Follmann, Markus; Stasch, Johannes-Peter; Knorr, Andreas; Schlemmer, Karl-Heinz; Redlich, Gorden Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1197 - 1200]