Syntheses and activities of backbone??side chain cyclic octapeptide ligands with N??functionalized phosphotyrosine for the N??terminal SH2??domain of the protein …

…, M Zacharias, S Reissmann

Index: Zoda, Mohammad Safa; Zacharias, Martin; Reissmann, Siegmund Journal of Peptide Science, 2010 , vol. 16, # 8 p. 403 - 413

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Citation Number: 3

Abstract

Abstract The protein tyrosine phosphatase SHP-1 plays an important role in many physiological and pathophysiological processes. This phosphatase is activated through binding of ligands to its SH2-domains, mainly to the N-terminal one. Based on a theoretical docking model, backbone-to-side chain cyclized octapeptides were designed as ligands. Assembly of such modelled structures required the synthesis of N-functionalized tyrosine ...