e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis of 2, 5-disubstituted 1, 3, 4-oxadiazine and 1, 3, 4-thiadiazine from substituted acetophenones and acid hydrazides using [hydroxyl (tosyloxy) iodo] benzene
NN Karade, JM Kondre, SV Gampawar…
Index: Karade, Nandkishor N.; Kondre, Jeevan M.; Gampawar, Sumeet V.; Shinde, Sandeep V. Synthetic Communications, 2009 , vol. 39, # 13 p. 2279 - 2287
Abstract A novel and direct method for the efficient synthesis of 2, 5-disubstituted 1, 3, 4- oxadiazines from the reactions of [hydroxy (tosyloxy) iodo] benzene with substituted acetophenones, followed by the treatment with acid hydrazide and K2CO3, is reported. The methodology is also extended to the synthesis of 5-aryl-6 H-1, 3, 4-thiadiazin-2-amine by using thiosemicarbazide under similar experimental conditions.
