Bioorganic & medicinal chemistry

A new class of nifuroxazide analogues: synthesis of 5-nitrothiophene derivatives with antimicrobial activity against multidrug-resistant Staphylococcus aureus

A Masunari, LC Tavares

Index: Masunari, Andrea; Tavares, Leoberto Costa Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 12 p. 4229 - 4236

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Citation Number: 130

Abstract

Hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) has been an increasing problem worldwide since the initial reports over 40years ago. To examine new drug leads with potential antibacterial activities, 14 p-substituted benzoic acid [(5-nitro- thiophen-2-yl)-methylene]-hydrazides were designed, synthesized, and tested against standard and multidrug-resistant S. aureus strains by serial dilution tests. All compounds ...