Synthesis of Aryl??Substituted Naphthalene??Linked Pyrrolobenzodiazepine Conjugates as Potential Anticancer Agents with Apoptosis??Inducing Ability

…, A Juvekar, S Sen, SM Zingde, M Pal??Bhadra

Index: Kamal, Ahmed; Reddy, M. Kashi; Ramaiah, M. Janaki; Srikanth; Rajender; Reddy, V. Santosh; Kumar, G. Bharath; Pushpavalli; Bag, Indira; Juvekar, Aarti; Sen, Subrata; Zingde, Surekha M.; Pal-Bhadra, Manika ChemMedChem, 2011 , vol. 6, # 9 p. 1665 - 1679

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Citation Number: 12

Abstract

Abstract A library of new aryl-substituted naphthalene C8-linked pyrrolo [2, 1-c][1, 4] benzodiazepine (PBD) conjugates with various linker architectures were designed, synthesized, and evaluated for their anticancer activity against a panel of 11 human cancer cell lines. All 32 conjugates show anticancer potential, with some of them exhibiting particularly high activity (0.01–0.19 μ M). Thermal denaturation studies showed effective ...