A new psoralen derivative with enlarged antiproliferative properties

…, JC González-Gómez, LG Pérez-Montoto…

Index: Dalla Via, Lisa; Gonzalez-Gomez, Jose Carlos; Perez-Montoto, Lazaro Guillermo; Santana, Lourdes; Uriarte, Eugenio; Marciani Magno, Sebastiano; Gia, Ornella Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 10 p. 2874 - 2876

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Citation Number: 12

Abstract

Following our results with benzopsoralens as potent photochemotherapeutic agents, we report the antiproliferative evaluation of nitrogenated isoster upon and without UVA irradiation. The evaluated pyridazinopsoralen showed a higher photochemotherapeutic activity with respect to the well-known drug, 8-MOP, and a significant cytotoxicity, also in the dark. This result enlarges the interest in this tetracyclic psoralen derivative skeleton in the ...