Synthesis of Novel 6′-Spirocyclopropyl-5′-Norcarbocyclic Adenosine Phosphonic Acid Analogues as Potent Anti-Hiv Agents

LJ Liu, E Kim, JH Hong

Index: Liu, Lian Jin; Kim, Eunae; Hong, Joon Hee Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 10 p. 784 - 797

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Citation Number: 7

Abstract

Novel 5′-norcarbocyclic adenosine phosphonic acid analogues with 6′-electropositive moiety such as spirocyclopropane were designed and synthesized from the commercially available diethylmalonate 5. Regioselective Mitsunobu reaction proceeded in the presence of an allylic functional group at a low reaction temperature in polar cosolvent [dimethylformamide (DMF)/1, 4-dioxane] to give purine analogue 15. To improve cellular ...