Chemical Science

Programmed synthesis of arylthiazoles through sequential C–H couplings

S Tani, TN Uehara, J Yamaguchi, K Itami

Index: Tani, Satoshi; Uehara, Takahiro N.; Yamaguchi, Junichiro; Itami, Kenichiro Chemical Science, 2013 , vol. 5, # 1 p. 123 - 135

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Citation Number: 74

Abstract

A programmed synthesis of privileged arylthiazoles via sequential C–H couplings catalyzed by palladium or nickel catalysts has been accomplished. This versatile protocol can supply all possible arylthiazole substitution patterns (2-aryl, 4-aryl, 5-aryl, 2, 4-diaryl, 2, 5-diaryl, 4, 5- diaryl, and 2, 4, 5-triaryl) from an unfunctionalized thiazole platform by 11 distinct synthetic routes. We have generated over 150 arylthiazoles by using this methodology. We have ...

~88%

~96%

~76%

~76%

~95%

~69%

~10%

~65%

~49%

~85%

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