The Houben-Hoesch synthesis of from activated aromatic substrates and nitriles in the presence of HC1 and ZnC1, has been reviewed by Ruske." An abnormal Houben-Hoesch reaction of resorcinol with f&ketonitriles, 5 proceeds first via the keto group and then the nitrile to afford coumarins. This reaction falls within the scope of the von Pechmann reaction. 6 This communication reports a drastic deviation from the normal Houben-Hoesch ...
![1-[bis(2,4,5-trimethoxyphenyl)methyl]-2,4,5-trimethoxybenzene Structure](https://image.chemsrc.com/caspic/355/14470-07-6.png)